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KMID : 0379119990270010082
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Korean Journal of Mycology
1999 Volume.27 No. 1 p.82 ~ p.86
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Hepatoprotective Kffect of Exo - polysaccharide Produced from Submerged Mycelial Culture of Ganoderma lucidum WK-003 by Using Industrial Grade Medium
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Abstract
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The production of hepatoprotective exo-polysaccharide by using synthetic and industrial grade media of the submerged mycelial culture of Ganoderma lucidum WK-003 was compared. The optimum concentrations of molasses and corn steep liquor (industrial grade) for the production of exo-polysaccharide were 5% and 2.5%, respectively. The productions of the exo-polysaccharide by using a 5ℓ jar fermenter with industrial grade medium and synthetic medium were 11.2 g D.W./ℓ and 7.2 g D.W./ℓ, respectively. Glutamic pyruvic transaminase (GPT) activities in the serum of intoxicated Sprague-Dawley rats by oral administration of the exo-polysaccharide produced from the industrial grade and synthetic media for 4 consecutive days were decreased from 704 IU/L to 356 IU/L and 704 IU/L to 349 IU/L, respectively.
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KEYWORD
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